Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8327030 | International Journal of Biological Macromolecules | 2018 | 45 Pages |
Abstract
The present research deals with the usefulness of isolated linseed polysaccharide (LP) as polymeric-blends with an anionic polymer, sodium alginate to prepare ionotropically cross-linking gelled mucoadhesive beads for controlled drug release. From the mature and ripe linseeds (Linum usitatisimum; family Linaceae), LP was isolated and its colour, odour, taste, solubility in water, pH and viscosity were studied. Isolated LP was also characterized by FTIR spectroscopy and 1H NMR analyses. LPâcalcium alginate beads loaded with diclofenac sodium were formulated via ionotropically crosslinking gelation method using calcium chloride as ionotropic crosslinker. These ionotropically crosslinked beads showed diclofenac sodium encapsulation efficiencies in these newly prepared beads were 60.78â¯Â±â¯2.47 to 93.16â¯Â±â¯4.08% and average bead-sizes of 1.17â¯Â±â¯0.10 to 1.33â¯Â±â¯0.12â¯mm. All LPâcalcium alginate beads loaded with diclofenac sodium demonstrated a sustained drug releasing profile over 8â¯h with a zero-order model of drug releasing (controlled drug releasing pattern). The LPâcalcium alginate beads loaded with diclofenac sodium displayed a pH responsive swelling and excellent biomucoadhesivity prospective with the intestinal mucosal tissue in both the acidic and alkaline pH (pHâ¯1.2 and 7.4, respectively). These beads were also characterized by SEM and FTIR spectroscopy.
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Authors
M. Saquib Hasnain, Poonam Rishishwar, Sanjay Rishishwar, Sadath Ali, Amit Kumar Nayak,