Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8327427 | International Journal of Biological Macromolecules | 2018 | 28 Pages |
Abstract
We isolated and purified polysaccharide from the Camellia oleifera Abel. seed cake (CCP) and studied its hypoglycemic activity in vitro. The molecular weight of CCP was 4736â¯Da and the monosaccharide molar composition ratio was: Xylose:Glucuronic acid:Galactosamine:Mannoseâ¯=â¯10.9:4.4:2.6:1.8. The CCP contained conjugated proteins and belonged to acidic polysaccharide, which can promote the consumption of the glucose in the medium by HepG2 cells within the range of 0.125-0.500â¯mg/mL. Relative consumption rate (RCR) of the glucose was the highest at 0.5â¯mg/mL, exceeded that of the metformin hydrochloride, as well as that of Tea Polysaccharide under the same concentration. A meaningful structure activity relationship (SAR) of hypoglycemia polysaccharides had established. This result suggests that CCP can be used as hypoglycemic medicine or health food.
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Authors
Sheng Zhang, Xiangzhou Li,