Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8327680 | International Journal of Biological Macromolecules | 2018 | 29 Pages |
Abstract
Câphycocyanin peptide (CPC) grafted Nâsuccinyl chitosan (NSC) was prepared via the catalysis of Microbial transglutaminase (MTGase). The single factor experiment displayed that the degree of substitution (DS) of Nâsuccinyl chitosanâCâphycocyanin peptide (NSCâCPC) depended on the reaction time, the reaction temperature and the reaction pH value. The CS, synthesized NSC and NSCâCPC were characterized by Fourier transform infrared spectroscopy (FT-IR). NSCâCPC showed excellent moisture absorption and retention ability. In vitro antioxidant activity assays demonstrated that, with the DS and concentration increasing of NSCâCPC, the scavenging activity of 1,1âDiphenylâ2âpicârylhydrazyl (DPPH) radical and hydroxyl radical increased. The methylthiazol tetrazolium (MTT) essay demonstrated that NSCâCPC inhibited Hela cells while promoted the proliferation of L929 mouse fibroblasts. In conclusion, these results suggested the potential application of NSCâCPC in pharmaceutical and biomedical fields.
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Authors
Wenyan Xu, Yao Xiao, Pengfeng Luo, Lihong Fan,