| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8327871 | International Journal of Biological Macromolecules | 2018 | 33 Pages |
Abstract
Bone is a highly integrative and dynamic tissue of the human body. It is continually remodeled by bone cells such as osteoblasts, osteoclasts. When a fraction of a bone is damaged or deformed, stem cells and bone cells under the influence of several signaling pathways regulate bone regeneration at the particular locale. Effective therapies for bone defects can be met via bone tissue engineering which employs drug delivery systems with biomaterials to enhance cellular functions by acting on signaling pathways such as Wnt, BMP, TGF-β, and Notch. This review provides the current understanding of polymers/bioceramics/bioactive compounds as scaffolds in activation of signaling pathways for the formation of bone.
Keywords
PLGAOPGP1NPOPNNICDTβRBSPHGSERKSBEMSCFGFTricalcium phosphatePLAosterixPCLHPDCtransforming growth factor–betaTGF-βTRAP5bIGFPGAJnkCSLRSKMAMLAuNPsc-Jun N-terminal kinaseMAPKALPAlkaline phosphataseAngiogeninOsteoprotegerinOsteopontinBoneTartrate-resistant acid phosphatase 5bOsxAngPolymersDrug deliveryBioactive compoundsNotch intracellular domainSARAMesenchymal stem cellsbone sialoproteinSmad binding elementVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)fibroblast growth factorTCPsmad anchor for receptor activationBMPSignaling pathwaysBone tissue engineeringGold nanoparticlesCollagen type 1HydroxyapatiteBTEribosomal protein S6 kinaseBone morphogenetic proteinPoly (lactic-co-glycolic acid)polyethylene glycolPolylactic acidPolycaprolactonePEGCol1extracellular signal-regulated kinase
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Authors
S. Harsha Rao, B. Harini, R. Pranav Kumar Shadamarshan, K. Balagangadharan, N. Selvamurugan,