Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8327978 | International Journal of Biological Macromolecules | 2018 | 37 Pages |
Abstract
This research was aimed to develop and evaluate nepafenac loaded silica nanoparticles dispersed in-situ gel system for the improved treatment of ocular diseases. The blank silica nanoparticles prepared by stober's process showed the particle size of 151â¯nm to 285â¯nm with the zeta potential of â19.6 to â31.9â¯mV. The nepafenac loaded silica nanoparticles were spherical in shape with smooth outer surface. The nepafenac loaded silica nanoparticles dispersed in poloxamer - chitosan in-situ gelling system showed gelling temperature of 32â¯Â°C with sustained release of nepafenac and higher permeation (58.79â¯Î¼g) across the goat cornea than poloxamer - poloxamer (21.18â¯Î¼g) in-situ gelling system. Hence the developed in-situ gelling system containing nepafenac loaded silica nanoparticle could be a promising tool for the topical delivery of drugs to the eye.
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Authors
Muthuselvam Paulsamy, Chandrasekar Ponnusamy, Mohananarayanan Palanisami, Gayathri Nackeeran, SivaSakthi Paramasivam, Abimanyu Sugumaran, Ruckmani Kandasamy, Subramanian Natesan, Rajaguru Palanichamy,