Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8328335 | International Journal of Biological Macromolecules | 2018 | 10 Pages |
Abstract
In present study, the soluble polysaccharides by enzyme-assisted extraction from Agaricus bisporus (EnAPS) and its purified fractions of EnAPS-1, -2 and -3 were successfully obtained, and the antioxidant activities and anti-aging effects were investigated. The in vitro antioxidant assay demonstrated that EnAPS-2 had superior scavenging activities on DPPH and hydroxyl radicals, chelating activities of Fe2+ and reducing power. The in vivo animal experiments showed that both EnAPS and its purifies fractions had potential anti-aging effects against the d-galctose-induced aging diseases on liver, kidney, brain and skin, possibly by increasing the antioxidant enzymes, reducing the lipid peroxidation, improving the organ functions and remitting the lipid metabolism. The conclusions demonstrated that the polysaccharides by A. bisporus might be suitable for applying functional foods and natural drugs in preventing and delaying the aging and its complications.
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Authors
Shangshang Li, Min Liu, Chen Zhang, Chengye Tian, Xiuxiu Wang, Xinling Song, Huijuan Jing, Zheng Gao, Zhenzhen Ren, Weiru Liu, Jianjun Zhang, Le Jia,