Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8328843 | International Journal of Biological Macromolecules | 2018 | 23 Pages |
Abstract
Dendrobium nobile is a medicinal herb in traditional China and Southeast Asian countries. Employing a rat model of ethanol-induced gastric ulcer, we examined the protective effect of polysaccharide (JCP) extracted from Dendrobium nobile and explored the related mechanisms. Oral administration with 100Â mg/kg and 300Â mg/kg body weight JCP for days can significant prevent the formation of gastric ulcer. Moreover, JCP pretreatment could alleviate ethanol-induced histological damage, antioxidant activities, the level of epidermal growth factor, gastric concentration of prostaglandin E, and regulate the signaling pathways of mitogen-activated protein kinases and matrix metalloproteinases. This study investigated the ethanol-induced gastric ulcer protective effect of JCP for the first time, and elucidated that the protective mechanisms.
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Authors
Yi Zhang, Hongxin Wang, Nana Mei, Chaoyang Ma, Zaixiang Lou, Wenping Lv, GuoHua He,