Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8328996 | International Journal of Biological Macromolecules | 2018 | 38 Pages |
Abstract
Carbon dioxide assisted particle formation combined with electrospraying using supercritical CO2 (scCO2) as an aid (Carbon Dioxide Assisted Nebulization-Electrodeposition, CAN-ED) was used to produce Bortezomib loaded poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) P(3HB-co-3HHx) nanoparticles for sustained release. The morphology and structure of the prepared nanoparticles were investigated by SEM, TEM and FT-IR spectroscopy. Average diameter of particles obtained was 155 nm and the average core sizes of P(3HB-co-3HHx) nanoparticles were between 6 and 13 nm. The drug loading capacity, drug release and stability of Bortezomib loaded P(3HB-co-3HHx) nanoparticles were analyzed. The maximum loading capacity was achieved at pH = 6.0 in phosphate buffer (K2HPO4/KH2PO4). It was found that temperature did not affect the stability of Bortezomib loaded nanoparticles and it was good both at 37 °C and 4 °C. This study pointed out that CAN-ED is a green method to produce P(3HB-co-3HHx) nanoparticles for pH responsive targeting of Bortezomib especially to parts of the body where size exclusion is not crucial.
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Authors
Ruken Esra DemirdöÄen, Fatih Mehmet Emen, Kasim Ocakoglu, Paramasivam Murugan, Kumar Sudesh, Göktürk AvÅar,