Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8329355 | International Journal of Biological Macromolecules | 2017 | 41 Pages |
Abstract
Human DHRS7 (SDR34C1) is one of insufficiently described enzymes of the short-chain dehydrogenase/reductase superfamily. The members of this superfamily often play an important pato/physiological role in the human body, participating in the metabolism of diverse substrates (e.g. retinoids, steroids, xenobiotics). A systematic approach to the identification of novel, physiological substrates of DHRS7 based on a combination of homology modeling, structure-based virtual screening and experimental evaluation has been used. Three novel substrates of DHRS7 (dihydrotestosterone, benzil and 4,4â²-dimetylbenzil) have been described.
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Authors
Lucie Zemanová, Palani Kirubakaran, Ignacio Hernando Pato, Hana Å tambergová, JiÅà VondráÅ¡ek,