Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8329741 | International Journal of Biological Macromolecules | 2016 | 7 Pages |
Abstract
In the current study, a series of polylactic acid and polylactic-co-glycolic acid were prepared in an easy, simple, safe and economically feasible way with yield% greater than 90%. Studying the effect of a catalyst on polymerization process was performed. Riboflavin (RF) was chosen as a model drug and microencapsulated in different (drug: polymer) ratios to modify its performance via o/w emulsion solvent evaporation technique and characterized in terms of the morphology and entrapment efficiency (E.E.) and evaluated via in vitro RF release studies. It has been found that, the release rate consists a burst release at the first 12Â h, followed by a gradual release over 3Â days. The cumulative riboflavin release from these microcapsules formulations at the end of 3Â days was 70% and 80% for PDLA and PDLAGA respectively. The kinetics of release profiles were zero order. The highest (E.E.) of RF obtained among all formulations was 85%.
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Authors
A.M. Abd El-Hay, A.M. Naser, A. Badawi, M.A. Abd El-Ghaffar, H. Abd El-Wahab, Doaa A. Helal,