Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8330082 | International Journal of Biological Macromolecules | 2015 | 6 Pages |
Abstract
The present study investigated in vitro the effects of sulphated heterorhamnan (Go3), iota-/nu-carrageenans (G3d and EHW-I) and arabinogalactan (ARAGAL) polysaccharides on macrophage activation and inhibition of intracellular amastigotes of Leishmania (L.) amazonensis. All the sulphated polysaccharides (Go3, G3d and EHW-I) promoted increased nitric oxide production varying from 71 to 110%. The leishmanicidal activity of all compounds was compared to the inhibition effect of Meglumine Antimoniate at 300 μg/mL (â¼79%), used as positive control. Inhibition of Leishmania (L.) amazonensis growth was 55% with 5 μg/mL of Go3, 50% and 98% to G3d and EHW-I, respectively at 10 μg/mL, and 88% with 10 μg/mL of ARAGAL. The superoxide anion scavenging activity for the sulphated polysaccharides varied from approximately 30-55% at 10 μg/mL. In conclusion, the results of the present study indicate the promising potential of these polysaccharides for the development of new alternative therapeutic agents against leishmaniasis.
Keywords
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Authors
Monica Mendes Kangussu-Marcolino, Marianna Maia Taulois do Rosário, Miguel Daniel Noseda, Maria Eugenia Rabello Duarte, Diogo Ricardo Bazan Ducatti, Juliana Emanuela Fogari Cassolato, Marcello Iacomini, Glaucia Regina Martinez,