| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8330275 | International Journal of Biological Macromolecules | 2016 | 8 Pages |
Abstract
- Synthesis and characterization of novel Ru(II) complexes (Ru-1 to Ru-8) bearing R-pdc, pbinh ligands and there in vitro cytotoxic activity.
- Some of these complexes exhibited more potent antiproliferative activity against human cancer cell lines than the standard drug cisplatin.
- Complex Ru-2 was the most active and 2-fold more potent than cisplatin against L1210 with IC50 value of 0.68 μmol/L, but was less potent against BEL7402 cell line.
- DNA-binding, DNA cleavage and protein binding properties of these ruthenium complexes are reported.
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Authors
Sreekanth Thota, Srujana Vallala, Rajeshwar Yerra, Daniel Alencar Rodrigues, Nulgumnalli Manjunathaiah Raghavendra, Eliezer J. Barreiro,