Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8330525 | International Journal of Biological Macromolecules | 2015 | 6 Pages |
Abstract
Biopolymer based pH-sensitive hydrogels were prepared using chitosan (CS) with polyethylene glycol (PEG) of different molecular weights in the presence of silane crosslinker. The incorporated components remain undissolved in different swelling media as they are connected by siloxane linkage which was confirmed by Fourier transform infrared spectroscopy. The swelling in water was enhanced by the addition of higher molecular weight PEG. The swelling behaviour of the hydrogels against pH showed high swelling in acidic and basic pH, whereas, low swelling was examined at pH 6 and 7. This characteristic pH responsive behaviour at neutral pH made them suitable for injectable controlled drug delivery. The controlled release analysis of Cefixime (CFX) (model drug) loaded CS/PEG hydrogel exhibited that the entire drug was released in 30Â min in simulated gastric fluid (SGF) while in simulated intestinal fluid (SIF), 85% of drug was released in controlled manner within 80Â min. This inferred that the developed hydrogels can be an attractive biomaterial for injectable drug delivery with physiological pH and other biomedical applications.
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Authors
Sadia Atta, Shaista Khaliq, Atif Islam, Irtaza Javeria, Tahir Jamil, Muhammad Makshoof Athar, Muhammad Imtiaz Shafiq, Abdul Ghaffar,