Possible peroxidase active site environment in amyloidogenic proteins: Native monomer or misfolded-oligomer; which one is susceptible to the enzymatic activity, with contribution of heme?

- Heme cofactor readily complexes with structural intermediates of amyloid aggregate.
- Histidine side chains are proposed as both distal and proximal residues required for proper function of peroxidase system.
- Amyloid aggregation appears to be correlated with peroxidase activity.