Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8330702 | International Journal of Biological Macromolecules | 2015 | 5 Pages |
Abstract
The study was designed to prepare and evaluate albumin nanoparticles containing antiviral drug abacavir sulphate. Various batches of albumin nanoparticles containing abacavir sulphate were prepared by desolvation method. The abacavir loaded particles were characterized for their yield, percentage of drug loading, surface morphology, particle size, surface charge, pattern of in vitro drug release and release mechanism studies. Drug loading ranged from 1.2 to 5.9%w/w. The mean particle size and the surface charge were 418.2Â nm and â40.8Â mV respectively. The in vitro drug release varied between 38.73 and 51.36%w/w for 24Â h. The n value for Korsmeyer-Peppas was 0.425 indicating Fickian type drug release. The preliminary findings indicated that albumin nanoparticles of abacavir can be prepared by desolvation method with good yield, high drug loading and sustained release.
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Authors
Barnabas Wilson, Latishkumar Paladugu, S.R. Brahmani Priyadarshini, J. Josephine Leno Jenita,