| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8331215 | International Journal of Biological Macromolecules | 2015 | 7 Pages |
Abstract
Runx2 is a master transcription factor for osteogenesis. The most important phenomenon that makes this protein a master regulator for osteogenesis is its structural integrity. In response to various stimuli, the domains in Runx2 interact with several proteins and regulate a number of cellular events via posttranslational modifications. Hence, in this review we summarized the structural integrity of Runx2 and its posttranslational modifications, especially the phosphorylation responsible for either stimulation or inhibition of its regulatory role in osteogenesis.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
S. Vimalraj, B. Arumugam, P.J. Miranda, N. Selvamurugan,