Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8331471 | International Journal of Biological Macromolecules | 2015 | 5 Pages |
Abstract
Herein, we have isolated a carbohydrate polymer (CP) containing fraction from its leaves by aqueous extraction method. CP is a branched polysaccharide containing, amongst others, 1,3-/1,3,6-linked galactopyranosyl, 1,5-/1,3,5-linked arabinofuranosyl and 1,2-/1,2,4-linked rhamnopyranosyl residues. Oral administration of CP fraction in doses of 25 and 50 mg kgâ1 body weight significantly inhibited the number of citric acid-induced cough efforts in guinea pigs in a dose dependent manner. Remarkably, CP did not altered specific airway resistance of animals significantly. Consequently, aqueous extraction method provided a molecular entity, which exhibited the cough suppressive activity: this could symbolize an attractive approach in phytotherapeutic treatment.
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Authors
Kanika Ghosh, Gabriela Nosalova, Sayani Ray, Veronika Sivova, Slavomir Nosal, Bimalendu Ray,