| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8331725 | International Journal of Biological Macromolecules | 2015 | 10 Pages |
Abstract
The present findings were aimed to develop an effective form of collagen-chitosan film to investigate the wound healing property in Wistar rats. Primarily, the acid-soluble collagen (ASC) isolated, structurally and physicochemically characterized. FT-IR and 1H NMR spectra were confirmed the collagen peptide crosslinks. The molecular weight of ASC subunits was about 86Â kDa and 79Â kDa, the proline and hydroxyproline content was 13.15% and 7.55%, respectively. In addition, collagen-chitosan films were successfully prepared in a controlled environment and characterized by FT-IR and DSC. In wound healing, the experimental animal model showed the increased wound size reduction in the CChF treated rats (96.25%) when compared to control rats (33.75%) followed by CF treated rats (65%) and ChF (55%). The histological results well supported these findings. It can be concluded that a better and faster epithelization was observed in the CChF group compared to the other groups.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Pasiyappazham Ramasamy, Annaian Shanmugam,