Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8331821 | International Journal of Biological Macromolecules | 2015 | 10 Pages |
Abstract
Present study describes the synthesis of carboxylmethyl guar gum (CMGG) from the native guar gum (GG). Further, the prepared CMGG is grafted with gelatin to form CMGG-g-gelatin and then mixed with curcumin to prepare a biomaterial. The resultant biomaterial is subjected to the analysis of 1H NMR, ATR-FTIR, TGA, SEM and XRD ensure the carboxymethylation and grafting. The results reveal that 45% of the amine groups of gelatin have been reacted with the COOH group of CMGG and 90-95% of curcumin is released from CMGG-g-gelatin after 96Â h of incubation in the phosphate buffer at physiological pH. In vitro cell line studies reveal the biocompatibility of the biomaterial and the antimicrobial studies display the growth inhibition against gram +ve and gram âve organisms at a considerable level. Overall, the study indicates that the incorporation of curcumin into CMGG-g-gelatin can improve the functional property of guar gum as well as gelatin.
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Authors
Piyali Jana Manna, Tapas Mitra, Nilkamal Pramanik, V. Kavitha, A. Gnanamani, P.P. Kundu,