Development and optimization of modified release IPN macromolecules of oxcarbazepine using natural polymers

- Novel IPN beads of oxcarbazepine were prepared using ionotropic gelation method.
- Sodium alginate and egg albumin (release retardant) were utilized as IPN.
- Drug loaded IPN beads were evaluated by needful parameters.
- The in vitro release indicated sustained release of oxcarbazepine over 8 h.
- Hixson-Crowell with anomalous non-Fickian diffusion release mechanism followed.
- Variables affected on beads were optimized using 32 full factorial design.