Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8332508 | International Journal of Biological Macromolecules | 2015 | 6 Pages |
Abstract
Polyelectrolyte complex beads based on N,N,N-trimethyl chitosan (TMC) and sodium alginate (ALG) were obtained. This biomaterial was characterised by FTIR, TGA/DTG, DSC and SEM analysis. The good properties of polyelectrolyte complex hydrogel beads were associated, for the first time, with gold nanoparticles (AuNPs). Through a straightforward methodology, AuNPs were encapsulated into the beads. The in vitro cytotoxicity assays on the Caco-2 colon cancer cells and healthy VERO cells showed that the beads presented good biocompatibility on both cell lines, whereas the beads loaded with gold nanoparticles (beads/AuNPs) was slightly cytotoxic on the Caco-2 and VERO cells.
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Authors
Alessandro F. Martins, Suelen P. Facchi, Johny P. Monteiro, Samara R. Nocchi, Cleiser T.P. Silva, Celso V. Nakamura, Emerson M. Girotto, Adley F. Rubira, Edvani C. Muniz,