| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8333156 | International Journal of Biological Macromolecules | 2014 | 24 Pages |
Abstract
Significant development has been achieved with bioceramics and biopolymer scaffolds in the construction of artificial bone. In the present study, we have developed and compared chitosan-micro hydroxyapatite (chitosan-mHA) and chitosan-nano hydroxyapatite (chitosan-nHA) scaffolds as bone graft substitutes. The biocompatibility and cell proliferation of the prepared scaffolds were checked with preosteoblast (MC3T3-E1) cells. Total Volume (TV), bone volume (BV), bone surface (BS), trabecular thickness (Tb.Th), trabecular number (Tb.N) and trabecular separation (Tb.Sp) were found to be higher in chitosan-nHA than chitosan-mHA scaffold. Hence, we suggest that chitosan-nHA scaffold could be a promising biomaterial for bone tissue engineering.
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Authors
Jong Seo Lee, Sang Dae Baek, Jayachandran Venkatesan, Ira Bhatnagar, Hee Kyung Chang, Hui Taek Kim, Se-Kwon Kim,