Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8333819 | International Journal of Biological Macromolecules | 2013 | 8 Pages |
Abstract
We herein report the anti-arthritic and immunosuppressive activities of some synthesized substituted terpenoidal structure. Forty-four triterpenoid derivatives 1-21 containing a carboxylic, ester, amide and ketone groups attached to a triterpene moiety were conveniently synthesized and screened for their anti-arthritic and immunosuppressive activities. Synthetic triterpenoidal structures linked to a different function groups seem to be a promising approach in the search for novel leads for potent anti-arthritic and immunosuppressive agents. The detailed synthetic pathways of obtained compounds and anti-arthritic and immunosuppressive activities were reported.
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Authors
Amer M. Alanazi, Mohamed A. Al-Omar, Mohamed M. Abdulla, Abd El-Galil E. Amr,