Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8333912 | International Journal of Biological Macromolecules | 2013 | 5 Pages |
Abstract
Agaricus brasiliensis is an edible mushroom, traditionally used for the treatment of several diseases. In this paper, a polysaccharide (PLS) from A. brasiliensis, its carboxymethylated (CPLS) and sulfated (SPLS) derivatives, as well as, fractions (F1-F3) obtained from the PLS were investigated for their effect in the replication of herpes simplex virus and bovine herpes virus in HEp-2 cell cultures. The PLS, SPLS and F3 inhibited both virus strains similarly, in a dose-dependent curve. F1, F2 and CPLS did not show significant effect even at higher concentrations. All the compounds showed neither virucidal or viral adsorption inhibition activities nor effect when cells were treated prior to infection. Our study demonstrated that the extracts of A. brasiliensis, can be promising for future antiviral drug design and its biotechnological production is economically feasible.
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Authors
Kristie Aimi Yamamoto, LÃgia Carla Faccin Galhardi, VinÃcius Pires Rincão, Sandra de Aguiar Soares, Ícaro Gusmão Pinto Vieira, Nágila Maria Pontes Silva Ricardo, Carlos Nozawa, Rosa Elisa Carvalho Linhares,