| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8334210 | International Journal of Biological Macromolecules | 2012 | 7 Pages |
Abstract
⺠Water-soluble gossypol derivative conjugated with N-polyvinylpyrrolidone has been synthesized. ⺠The new gossypol derivative has shown a high antioxidant and antiradical activities. ⺠Significant protection of mitochondria against oxidative damage in vivo has been demonstrated. ⺠New water-soluble gossypol derivative can be considered for treatment of diseases that are characterized by oxidative damage.
Keywords
PVPDPPHLCLTBADCsHRPLPOLPELPCCCl41,1-diphenyl-2-picrylhydrazyl2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)ABTS+ROSdiene conjugatesThiobarbituric acidOxidative phosphorylationLyso-phosphatidylcholinethiobarbituric acid reactive substancesHorseradish peroxidaseLipid peroxidationCarbon tetrachlorideGossypolReactive oxygen species
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Authors
Maksim Ionov, Nataliya V. Gordiyenko, Izabela Zukowska, Elmira Tokhtaeva, Olga A. Mareninova, Nina Baram, Khairulla Ziyaev, Kuralbay Rezhepov, Maria Zamaraeva,