| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8334222 | International Journal of Biological Macromolecules | 2012 | 6 Pages |
Abstract
⺠Stability of polyglutamine stretch may determine stability of proteins. ⺠Normal huntingtin shows complete recovery of structure following denaturation. ⺠Refolding of secondary structure of denatured mutant protein is not complete. ⺠Tertiary structure of normal huntingtin is more stable than mutant protein. ⺠Aggregation of mutant huntingtin may be due to instability of polyglutamine stretch.
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Authors
Shivang N. Vachharajani, Rajeev Kumar Chaudhary, Shivcharan Prasad, Ipsita Roy,