Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8334250 | International Journal of Biological Macromolecules | 2012 | 9 Pages |
Abstract
⺠Binding of isoflavonoid diadzein with human hemoglobin was investigated. ⺠Spectroscopic, molecular docking and dynamics studies were carried out. ⺠β-Trp-37 serves as good indicator for the microenvironment of diadzein inside the protein. ⺠Diadzein does not interfere with the functionality of the heme of hemoglobin. ⺠Overall secondary structure of the protein remains unchanged in the presence of the drug.
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Authors
Bidisha Sengupta, Sandipan Chakraborty, Maurice Crawford, Jasmine M. Taylor, Laura E. Blackmon, Pradip K. Biswas, Wolfgang H. Kramer,