| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8334321 | International Journal of Biological Macromolecules | 2012 | 8 Pages |
Abstract
⺠Homocysteine thiolactone (HCTL) augmented rate of insulin unfolding, increased solvent-exposed hydrophobic regions and induced a transition from α-helix into predominantly β-sheet structure. ⺠HCTL markedly enhanced the quantity of insulin fibril formation in both agitating and non-agitating systems. ⺠Insulin fibrils obtained in the presence of HCTL and those collected earlier in the pathway of insulin fibrillation displayed higher cytotoxicity against cancer cells. ⺠Results of this study may suggest HCTL as a possible contributing factor to the pathology of insulin fibrils.
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Authors
Reza Yousefi, Shima Jalili, Parnian Alavi, Ali-Akbar Moosavi-Movahedi,