| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8334484 | International Journal of Biological Macromolecules | 2012 | 9 Pages |
Abstract
⺠Calcium alginate/gum Arabic beads containing glibenclamide were prepared by ionotropic gelation method. ⺠The effects of amounts of sodium alginate and gum Arabic on drug encapsulation and drug release were optimized by central composite design. ⺠The optimized beads showed higher drug encapsulation and sustained drug release over 7 h of dissolution. ⺠The drug release followed first-order model over a period of 7 h with anomalous (non-Fickian) diffusion mechanism. ⺠These newly developed beads are suitable for sustained delivery of glibenclamide for prolonged period.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Amit Kumar Nayak, Biswarup Das, Ruma Maji,