Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8334487 | International Journal of Biological Macromolecules | 2012 | 7 Pages |
Abstract
Porous hydroxyapatite (HAp)/chitosan-alginate composite scaffolds were prepared through in situ co-precipitation and freeze-drying for bone tissue engineering. The composite scaffolds were highly porous and interconnected with a pore size of around 50-220 μm at low concentrations of HAp. As the HAp content increased, the porosity of the scaffolds decreased from 84.98 to 74.54%. An MTT assay indicates that the obtained scaffolds have no cytotoxic effects on MG-63 cells, and that they have good biocompatibility. An implantation experiment in mouse skulls revealed that the composite scaffold provides a strong positive effect on bone formation in vivo in mice. Furthermore, that HAp/chitosan-alginate composite scaffold has been shown to be more effective for new bone generation than chitosan-alginate scaffold.
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Authors
Hyeong-Ho Jin, Dong-Hyun Kim, Tae-Wan Kim, Keun-Koo Shin, Jin Sup Jung, Hong-Chae Park, Seog-Young Yoon,