Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8334541 | International Journal of Biological Macromolecules | 2012 | 8 Pages |
Abstract
We herein report the anti-Alzheimer activity of some synthesized heterocyclic pyrimidine and thiopyrimidine derivatives fused with steroidal structure. Twenty-one of these compounds were synthesized and conveniently screened for their anti-Alzheimer activities using of Flurbiprofen as the reference drug. Some of these compounds were demonstrated to exhibit remarkable activity and their β-amyloid (Aβ) lowering results as IC50 values reported.
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Authors
Mohamed M. Abdalla, Mohamed A. Al-Omar, Rashad A. Al-Salahi, Abdel-Galil E. Amr, Nermien M. Sabrye,