Article ID Journal Published Year Pages File Type
8334805 International Journal of Biological Macromolecules 2012 8 Pages PDF
Abstract
► Berberine upon biotransformation yields chiefly dihydroxyberberine. ► Dihydroxyberberine binds to PLA2 in an inverted orientation with respect to berberine. ► Biotransformation of berberine enhances its PLA2 inhibition.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Inverted binding due to a minor structural change in berberine enhances its phospholipase A2 inhibitory effect
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