| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8335421 | International Journal of Biological Macromolecules | 2012 | 6 Pages |
Abstract
The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased swelling, decreased degradation, increased protein adsorption, and increased antibacterial activity. The CS/nHAp/nCu-Zn scaffolds had no toxicity towards rat osteoprogenitor cells. So the developed CS/nHAp/nCu-Zn scaffolds have advantageous and potential applications over the CS-nHAp scaffolds for bone tissue engineering.
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Authors
Anjali Tripathi, Sekaran Saravanan, Soumitri Pattnaik, Ambigapathi Moorthi, Nicola C. Partridge, Nagarajan Selvamurugan,