Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8335499 | International Journal of Biological Macromolecules | 2011 | 7 Pages |
Abstract
The main aim of this research is to study the in vitro photocytotoxicity and cellular uptake of biodegradable polymeric nanoparticles loaded with photosensitizer mTHPP. As the first part of a continued research on conversion of N-sulfonato-N,O-carboxymethylchitosan (NOCCS) to useful biopolymer-based materials, large numbers of carboxylic functional groups were introduced onto NOCCS by grafting with polymethacrylic acid (PMAA). The free radical graft copolymerization was carried out at 70 °C, bis-acrylamide as a cross-linking agent and persulfate as an initiator. These results show that the nanoparticles have high loading capacity and stability. These nanoparticles are suitable as carriers for photodynamic therapy in vivo.
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Authors
Mohammad Reza Saboktakin, Roya M. Tabatabaie, Abel Maharramov, Mohammad Ali Ramazanov,