| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8335611 | International Journal of Biological Macromolecules | 2011 | 5 Pages |
Abstract
A novel drug delivery system for the treatment of brain tumors was formulated by methotrexate (MTX)-loaded polymeric nanoparticles (NPs) based on Glycol chitosan (GCS) and Dextran sulfate (DS). The physicochemical properties of resulting particles were investigated, evidencing the contribution of these nanoparticles for brain targeting. In vitro release of MTX was also evaluated. The GCS-DS nanoparticles have been developed based on the modulation of ratio show promise as a system for controlled delivery of the drug to the brain.
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Authors
Mohammad Reza Saboktakin, Roya M. Tabatabaie, Abel Maharramov, Mohammad Ali Ramazanov,