| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8336181 | Journal of Chemical Neuroanatomy | 2018 | 31 Pages |
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) have been in use for many years and constitute a large part of prescriptions issued in daily practice. Although NSAIDs are used for many diseases in neurology, they have also been tested as a new therapeutic option for various other diseases. While their effects on headache and cerebrovascular diseases are well known, little is known about their impact on neurodegenerative diseases. This review discusses the use, effects and safety of NSAIDs in neurological diseases.
Keywords
mitogen-activated protein kinase/extracellular signal-regulated kinaseERKPMCSNCGPEPPARγSNRAPPVA/VLpKaCREBTNFR1Substantia nigra pars reticulataGDNFSTNCB2RPKCDAergicPGSNF-kBIL-6COXNSAIDSNFsJAK/STATMAPKMAPK/ERKROScyclooxygenaseamyotrophic lateral sclerosisArachidonic acidinterleukin-6Alzheimer’s diseaseALSParkinson's diseaseThromboxanessubstantia nigra pars compactatumor necrosis factor-αextracellularIntracellularNon-steroidal anti-inflammatory drugsSMACNSDopaminergiccentral nervous systemNeurotrophic factorsGlial cell line-derived neurotrophic factorTNF-αnuclear factor kappa Btransmembraneprimary motor cortexPre-motor cortexlipoxygenasePPNsupplementary motor areaMultiple sclerosisPedunculopontine nucleusSubthalamic nucleuscAMP-response element binding proteinamyloid precursor proteinprotein kinase AProtein kinase Cmitogen-activated protein kinaseProstaglandinsextracellular signal-regulated kinaseReactive oxygen speciescannabinoid CB2 receptortumor necrosis factor receptor 1
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Authors
Murat Terzi, Gamze Altun, Sedat Åen, Adem Kocaman, Arife Ahsen Kaplan, Kıymet Kübra Yurt, Süleyman Kaplan,