Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8336253 | Journal of Chemical Neuroanatomy | 2014 | 6 Pages |
Abstract
We have examined whether calcitonin gene-related peptide-immunoreactive (CGRP-ir) neurons in the vagal and glossopharyngeal ganglia innervate the larynx. Many CGRP-ir neurons were located mostly in the superior glossopharyngeal-jugular ganglion complex that was fused the superior glossopharyngeal ganglion and the jugular ganglion in the cranial cavity. When Fluorogold was applied to the cut end of the superior laryngeal nerve (SLN) or the recurrent laryngeal nerve (RLN), many Fluorogold-labeled neurons were found in the superior glossopharyngeal-jugular ganglion complex and the nodose ganglion. Double-labeling for CGRP and Fluorogold showed that about 80% of Fluorogold-labeled neurons in the superior glossopharyngeal-jugular ganglion complex expressed CGRP-like immunoreactivity in the case of application to the SLN, and about 50% of Fluorogold-labeled neurons expressed CGRP-like immunoreactivity in the case of the RLN. Only a few double-labeled neurons were found in the nodose ganglion. The number of the Fluorogold-labeled neurons and double-labeled neurons in the superior glossopharyngeal-jugular ganglion complex in the case of the SLN was larger than that in the case of the RLN. These results indicate that sensory information from the larynx might be conveyed by many CGRP-ir neurons located in the superior glossopharyngeal-jugular ganglion complex by way of the SLN and the RLN.
Keywords
WGANTSIJVRLNPACAPFluorogoldVR1CGRPSLNN10CTBHRPTRPV1DAB3,3′-diaminobenzidineimmunoreactiveImmunohistochemistrySpinal trigeminal tractJugular foramenretrograde tracingglossopharyngeal nerverecurrent laryngeal nervesuperior laryngeal nervevagus nerveNucleus tractus solitariiInternal jugular veinHorseradish peroxidasepituitary adenylate cyclase-activating polypeptidecalcitonin gene-related peptidecholera toxin subunit BCranial gangliaNodose ganglionWheat germ agglutininVanilloid receptor 1
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Tetsu Hayakawa, Sachi Kuwahara-Otani, Seishi Maeda, Koichi Tanaka, Makoto Seki,