Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8336340 | The Journal of Nutritional Biochemistry | 2018 | 26 Pages |
Abstract
Milk oligosaccharides (MO) selectively increase the growth of Bifidobacterium infantis (B. infantis). This study examines the effects of bovine MO and B. infantis in preventing nonalcoholic steatohepatitis (NASH) in Western diet (WD)-fed bile acid (BA) receptor FXR (farnesoid x receptor) knockout (KO) mice. WD-fed FXR KO mice have cancer-prone NASH and reduced B. infantis. MO and/or B. infantis supplementation improved their insulin sensitivity and reduced hepatic inflammation. Additionally, B. infantis, but not MO, decreased hepatic triglyceride and cholesterol. A combination of both further reduced hepatic cholesterol, the precursor of BAs. All three treatments modulated serum and hepatic BA profile. Moreover, B. infantis and MO decreased hepatic CYP7A1 and induced Sult2a1, Sult2a2, and Sult2a3 suggesting reduced BA synthesis and increased detoxification. Furthermore, B. infantis and MO increased ileal BA membrane receptor TGR5-regulated signaling. Together, via BA-regulated signaling, synbiotics B. infantis and MO have their unique and combined effects in reversing NASH.
Keywords
UDCACDCADCAHDCAFXRSCFAALTTGR5TCDCATDCATCATLCAbcoAfarnesoid X receptorALPAlkaline phosphatasenonalcoholic steatohepatitisChenodeoxycholic acidDeoxycholic acidTaurodeoxycholic acidtaurochenodeoxycholic acidTaurolithocholic acidTaurocholic acidBile acidHyodeoxycholic acidCholic acidMilk oligosaccharidesUrsodeoxycholic acidButyrate kinaseBUKDysbiosisWestern dietShort chain fatty acidLiver cancerMicrobiotaknockoutNash wild typeProbioticsPrebiotics
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Authors
Prasant Kumar Jena, Lili Sheng, Nidhi Nagar, Chao Wu, Daniela Barile, David A. Mills, Yui-Jui Yvonne Wan,