Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8336349 | The Journal of Nutritional Biochemistry | 2018 | 39 Pages |
Abstract
Neuroinflammation is documented to be the major culprit of Alzheimer's disease. Lycopene (LYC), a fat soluble carotenoid, exhibits neuroprotective function in several neurodegenerative disorders. However, the effects of LYC to countering systemic inflammation-induced amyloidogenesis and memory deficiency remain to be elucidated. In current study, 3-month-old male C57BL/6J mice were treated with 0.03% LYC (w/w, mixed into normal chow) for 5 weeks. The mice were then treated by intraperitoneal injection of LPS (0.25mg/kg) for 9 days. It was found that LYC inhibited LPS-induced memory loss by behavior tests including Y-maze test and Morris water test. Meanwhile, LYC prevented LPS-induced accumulation of Aβ, levels of amyloid precursor protein (APP), and suppressed neuronal β-secretase BACE1 and elevated the expressions of α-secretase ADAM10. Furthermore, LYC down-regulated the expression of IBA-1 (a marker of microglia activation), reduced the levels of inflammatory mediators and inhibited oxidative stress in LPS-treated mice. Moreover, LYC suppressed the phosphorylation of MAPKs, NFκB, and activated Nrf2 signaling pathways in LPS-treated BV2 microglial cells. Therefore, our study indicated that LYC could ameliorate LPS-induced neuroinflammation, oxidative stress, amyloidogenesis and cognitive impairments possibly through mediating MAPKs, NFκB and Nrf2 signaling pathways, indicating that LYC might be a nutritional preventive strategy in neuroinflammation-related diseases such as AD.
Keywords
LYCBACE1GSHNACCATAβCOX-2JnkiNOSIL-6LPSAPPIL-1βIL-10MMPβ-secretase 1ADAM 10c-Jun N-terminal kinaseERK1/2MAPKNFκBROSamyloid-betaAmyloidogenesisCognitive impairmentsNeuroinflammationIHCImmunohistochemistryInterleukin 10interleukin 6Interleukin-1 betaAlzheimer’s diseaseParkinson’s diseaseOxidative stressCNShematoxylin-eosin stainingSODinducible nitric oxide synthaseSuperoxide dismutasecentral nervous systemCyclooxygenase-2nuclear factor kappa BlipopolysaccharideLycopenematrix metalloproteinaseamyloid precursor proteinmitogen-activated protein kinaseCatalaseExtracellular signal-regulated kinases 1/2GlutathioneReactive oxygen species
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Authors
Jia Wang, Lixia Li, Zhuo Wang, Yifan Cui, Xintong Tan, Tian Yuan, Qian Liu, Zhigang Liu, Xuebo Liu,