Article ID Journal Published Year Pages File Type
8336601 The Journal of Nutritional Biochemistry 2016 56 Pages PDF
Abstract
Effects of SFN on dysregulated metabolic parameters and injury-induced neointima formation in western diet (HFHS)-fed obese C57BL/6 J mice. SFN treatment attenuates weight gain and eWAT weight and improves systemic metabolic abnormalities (e.g., ↓ plasma leptin and insulin, improves HOMA-IR and glucose tolerance, and lowers plasma triglycerides/FFA and systolic blood pressure). In addition, SFN suppresses injury-induced intimal hyperplasia in the femoral artery and inhibits leptininduced VSMC proliferation by targeting p70S6K/S6 signaling. The use of SFN as a dietary supplement may provide a rational prophylactic approach to target restenosis after angioplasty in diet-induced obesity.146
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