Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis

Article ID	Journal	Published Year	Pages	File Type
8337297	The Journal of Nutritional Biochemistry	2013	10 Pages	PDF

Abstract

These data suggest that, when co-ingested with ethanol, dietary fat differentially contributes to dysregulation of adiponectin-dependent activation of the AMPK pathway in the liver of mice.

Keywords

LKB1 sterol response element binding protein 1 VLCAD ELOVL6 LCAD stearoyl CoA desaturase 1 SCD-1 MCAD ELOVL5 ATP citrate lyase ACLY SREBP ChREBP CYP2E1 AMPK ACC ALT PP2A AMP-activated protein kinase ALD Alanine aminotransferase malic enzyme short-chain acyl-CoA dehydrogenase Hepatic steatosis acetyl coA carboxylase fatty acid synthase Alcohol alcoholic liver disease Dietary fat Medium-chain acyl-CoA dehydrogenase Long-chain acyl-CoA dehydrogenase cytochrome P450 2E1 Fasn carbohydrate response element binding protein protein phosphatase 2A Scad liver kinase B1

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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis

Authors

Colin T. Shearn, Rebecca L. Smathers, Hua Jiang, David J. Orlicky, Kenneth N. Maclean, Dennis R. Petersen,