Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8337422 | The Journal of Nutritional Biochemistry | 2013 | 11 Pages |
Abstract
Purple sweet potato color (PSPC), a class of naturally occurring anthocyanins, has been reported to possess a variety of health-promoting properties. Emerging evidence indicates that PSPC can suppress postprandial hyperglycemia via inhibition of α-glucosidases. However, the protective effects of PSPC on hepatic insulin resistance and the precise mechanisms underlying these protective effects have never been investigated. In this study, our data showed that PSPC effectively improved the fasting blood glucose level, glucose and insulin tolerance by suppressing reactive oxygen species (ROS) production and by restoring glutathione (GSH) content and antioxidant enzymes' activities. PSPC further prevented the oxidative-stress-mediated endoplasmic reticulum (ER) stress in the livers of high-fat-diet (HFD)-treated mice. Moreover, PSPC dramatically suppressed the c-Jun-N-terminal kinase 1 and I kappa B kinase β activation and nuclear factor-kappa B p65 nuclear translocation caused by oxidative and ER stress in the livers of HFD-treated mice. Ultimately, PSPC notably restored the impairment of the insulin receptor substrate-1/phosphoinositide 3 kinase/protein kinase B (Akt) insulin signaling in the livers of HFD-treated mice. In conclusion, our findings indicate that PSPC protected against HFD-induced hepatic insulin resistance via decreasing ROS level and blocking ROS-mediated ER stress.
Keywords
NAFLDALTHFDIRSGPXGSK-3βT2DeIF2αJnkIKKc-Jun-N-terminal kinasePspCIkB kinasePI3KNF-κBROSASTAspartate aminotransferaseAlanine aminotransferaseER stressEndoplasmic reticulum stressNonalcoholic fatty liver diseasetriglycerideOxidative stressType 2 diabeteshigh-fat dietInsulin receptor substratesSODsuperoxide dismutaseseukaryotic translation initiation factor 2αnuclear factor-κBphosphoinositide 3 kinaseInsulin resistanceprotein kinase BPERKtotal cholesterolglutathione peroxidaseReactive oxygen species
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Authors
Zi-Feng Zhang, Jun Lu, Yuan-Lin Zheng, Dong-Mei Wu, Bin Hu, Qun Shan, Wei Cheng, Meng-Qiu Li, Yuan-Yuan Sun,