| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8337705 | The Journal of Nutritional Biochemistry | 2012 | 7 Pages |
Abstract
TPH intake significantly increased the plasma TRP/large neutral amino acid ratio (P<.0001) in the Lâ²/Lâ² group (70%) compared to the Sâ²/Sâ² group (30%). TPH reduced food intake in both groups, but in the Lâ²/Lâ² group, it also reduced stress-induced negative mood (P=.037) and the desire for sweet, high-fat foods (P=.011) regardless of dietary restraint. Conclusions: Since TPH caused a greater increase in the plasma TRP/large neutral amino acid ratio in the Lâ²/Lâ² group compared to Sâ²/Sâ² group, the exclusive beneficial effects of Lâ²/Lâ² genotype may be due to enhanced brain 5-HT function.
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Authors
C. Rob Markus, Ellen Verschoor, Tom Smeets,