Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8337815 | The Journal of Steroid Biochemistry and Molecular Biology | 2018 | 20 Pages |
Abstract
SOAT substrates from the group of sulfated steroids are characterized by a planar and lipophilic steroid backbone in trans-trans-trans conformation of the rings and a negatively charged mono-sulfate group at positions 3Ⲡor 17Ⲡwith flexibility for α- or β- orientation. Furthermore, 5α-reduction, 16α-hydroxylation, and 17α-hydroxylation are acceptable for SOAT substrate recognition, whereas addition of a second negatively charged sulfate group seems to abolish substrate binding to SOAT, and so 17β-estradiol-3,17-disulfate is not transported by SOAT.
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Authors
Gary Grosser, Josefine Bennien, Alberto Sánchez-Guijo, Katharina Bakhaus, Barbara Döring, Michaela Hartmann, Stefan A. Wudy, Joachim Geyer,