Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8338092 | The Journal of Steroid Biochemistry and Molecular Biology | 2016 | 8 Pages |
Abstract
Across 473,731CpG DNA methylation sites in cord blood DNA, none were strongly associated with maternal 25-hydroxyvitamin D after adjusting for multiple tests (false discovery rate (FDR)Â >Â 0.5; 473,731 tests). A meta-analysis of the results from both cohorts, using the Fisher method for combining p-values, also did not strengthen findings (FDRÂ >Â 0.2). Further exploration of a set of CpG sites in the proximity of four a priori defined candidate genes (CYP24A1, CYP27B1, CYP27A1 and CYP2R1) did not result in any associations with FDRÂ <Â 0.05 (56 tests). In this large genome wide assessment of the potential influence of maternal vitamin D status on DNA methylation, we did not find any convincing associations in 1416 newborns. If true associations do exist, their identification might require much larger consortium studies, expanded genomic coverage, investigation of alternative cell types or measurements of 25-hydroxyvitamin D at different gestational time points.
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Authors
M. Suderman, L.C. Stene, J. Bohlin, C.M. Page, K. Holvik, C.L. Parr, M.C. Magnus, S.E. HÃ¥berg, B.R. Joubert, M.C. Wu, S.J. London, C. Relton, W. Nystad,