Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8338449 | The Journal of Steroid Biochemistry and Molecular Biology | 2014 | 8 Pages |
Abstract
Incubation of stably transfected cell lines with doxycycline or progesterone alone, did not change expression of any endogenous gene. Expression of activated human PR-B or the chimera of human BUS with the canine PR resulted in differential expression of >500 genes whereas the activated cPR-B regulated only a subset of 40 genes and to a limited extent. The relevance of the marginal transactivation potential or the consequence of a lack of cPR-B function for the carcinogenesis of mammary gland tumors is discussed.
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Authors
Ana Gracanin, Fabiana A. Voorwald, Monique van Wolferen, Elpetra Timmermans-Sprang, Jan A. Mol,