| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8338758 | The Journal of Steroid Biochemistry and Molecular Biology | 2014 | 11 Pages |
Abstract
- Several analogues of diosgenin were synthesised by modifying at spiroketal ring.
- Analogue 15 significantly inhibits TNF-α, IL-6 and IL-1β in LPS-induced sepsis model.
- Therapeutic efficacy of analogue 15 was without any toxic effect on mice.
- Strong binding affinity of analogue 15 to the active site of inflammatory proteins.
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Authors
Monika Singh, A.A. Hamid, Anil K. Maurya, Om Prakash, Feroz Khan, Anant Kumar, O.O. Aiyelaagbe, Arvind S. Negi, Dnyaneshwar U. Bawankule,