In silico methods in the discovery of endocrine disrupting chemicals

- EDCs interfere with nuclear receptors and hormone-synthesizing enzymes.
- The mechanism of action for most EDCs is unknown.
- In silico methods are powerful tools for activity predictions and profiling
- There are currently only few reports on using in silico methods in the search for EDC.
- We review methods and studies on EDCs using virtual screening and in vitro testing.