| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8339015 | The Journal of Steroid Biochemistry and Molecular Biology | 2013 | 23 Pages |
Abstract
⺠The structures of oestrogen-metabolising enzymes are discussed and compared. ⺠Substrate recognition and reaction mechanisms of these enzymes are discussed. ⺠The impact of structure on inhibitor design is briefly mentioned.
Keywords
DHEA(S)S-COMT17β-Hydroxysteroid dehydrogenaseDNCPAPCOMTMB-COMT17β-HSDSAMFormylglycineNADPHSDRE2B3′-phosphoadenosine-5′-phosphosulfateNADP+PAPsS-adenosyl methioninearomataseestetrolOestrogenestriolShort-chain dehydrogenase/reductaseProtein structureSulfatasesulfotransferaseReaction mechanismnicotinamide adenine dinucleotide phosphate (reduced)catechol-o-methyl transferaseEstrogen receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Mark P. Thomas, Barry V.L. Potter,