Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8339062 | The Journal of Steroid Biochemistry and Molecular Biology | 2013 | 56 Pages |
Abstract
⺠Human skin produces and metabolizes glucocorticosteroids. ⺠Human skin produces and metabolizes sex hormones. ⺠Cutaneous steroidogenesis is regulated by local factors and UVR. ⺠Skin derived steroids regulate activity of skin immune system. ⺠Dysregulation of cutaneous steroidogenesis can lead to inflammatory or autoimmune disorders.
Keywords
SF-13β-HSD17β-HSDACTHERRinfcAMP/PKA5αRDAX-1CYP11B1CYP11B2GM-CSFUVRNFkBT helperDPCsNHEKsCYP21Deoxycorticosterone3β-Hydroxysteroid dehydrogenase17β-Hydroxysteroid dehydrogenaseCYP11A1DHEAECMCytochrome P450 side-chain cleavage enzymeDHTDOCCRH3α-HSDSSCcytochrome P450 17α-hydroxylase/17,20-lyaseTGFβPOMCdehydroepiandrosteroneERE21-Hydroxylase3α-hydroxysteroid dehydrogenase5α-reductaseAndrogenEstradiolEstroneEstrogensystemic sclerosisUltraviolet radiationinterferonTransforming growth factor βtestosteronecluster of differentiationDihydrotestosteroneStardermal papilla cellsSkin immune systemSteroidogenic factor 1granulocyte-macrophage colony-stimulating factorestrogen response elementnuclear factor kappa-light-chain-enhancer of activated B cellsHair folliclelupus erythematosusExtracellular matrixSubstance Pmajor histocompatibility complexMHCHPAadrenocorticotropic hormonecorticotrophin releasing hormoneSteroidogenic acute regulatory proteincAMP-dependent protein kinase Aproopiomelanocortinnormal human epidermal keratinocytesGlucocorticoidsestrogen-related receptorMineralocorticoid receptorglucocorticoid receptor
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Authors
Andrzej Slominski, Blazej Zbytek, Georgios Nikolakis, Pulak R. Manna, Cezary Skobowiat, Michal Zmijewski, Wei Li, Zorica Janjetovic, Arnold Postlethwaite, Christos C. Zouboulis, Robert C. Tuckey,